Deliverable 5.1 has been made available at the Project Web Site. Since the beginning of the project, we analysed a computational model of brain energy metabolism using a new approach to try to understand what biological processes influence the generation of signals from various brain imaging modalities, and how this would influence the kind of biological information that can be assessed using the new modality prototyped by the GAMMA-MRI consortium. We also expanded our computational framework in new directions. In this report, we aim to describe the result of these efforts, the initial conclusions that we have reached, and discuss future work.