Gamma MRI will develop a clinical molecular imaging device based on the physical principle of anisotropic gamma emission from hyperpolarised metastable xenon, based on a revolutionary technology, allowing the simultaneous exploitation of the sensitivity of gamma (γ) detection and the spatial resolution and flexibility of MRI.
At the end of the project, Gamma MRI will deliver a working prototype for in vivo molecular imaging, including the production of hyperpolarised gamma-emitting xenon isomers, preserving hyperpolarisation until delivery to targeted organ, developing advanced image acquisition and reconstruction using physics- and artificial intelligence- based approaches, designing and assembling the prototype upon a low field versatile magnet and implementing the first preclinical Gamma MRI brain imaging experiment.
To provide the overall project direction with a project management structure that ensures an efficient operational management including administrative, financial and legal issues, and appropriate liaison with the European Commission (EC).
To maintain and maximise polarisation of mXe with Spin-exchange Optical Pumping, explore Dynamic Nuclear Polarization (DNP).
To explore best K-space sampling strategies and simulate setup’s response to γ radiation.
To define and develop the hardware and software configuration of the γMRI prototype.
To develop a biophysical model of mXe tracer distribution and dynamics to perform first preclinical proof-of-principle γMRI brain imaging experiment and apply the technique to a rodent model of stroke.
To design a plan for optimal communication and undertake extensive dissemination activities to maximize awareness of this innovation.
The project is currently at month 24th out of the 42 months foreseen. The tasks of the project are progressing according to planning and we are happy to inform that some important milestones have been achieved already; such as the construction of the magnet, the acquisition of our first image and the availability of the first drat of the exploitation plan. On the other hand, laboratory work is on-going and the other tasks are also achieving good progress as well. The details on the progress of the different WPs can be seen in the progress bars below. The public deliverables can be downloaded at this web site.