Technology:

Gamma-MRI will develop a clinical molecular imaging device based on the physical principle of anisotropic gamma emission from hyperpolarised metastable xenon, based on a revolutionary technology, allowing the simultaneous exploitation of the sensitivity of gamma (γ) detection and the spatial resolution and flexibility of MRI.

Expected Results:

At the end of the project, γMRI will deliver a working prototype for in vivo molecular imaging, including the production of hyperpolarised gamma-emitting xenon isomers, preserving hyperpolarisation until delivery to targeted organ, developing advanced image acquisition and reconstruction using physics- and artificial intelligence- based approaches, designing and assembling the prototype upon a low field versatile magnet and implementing the first preclinical Gamma-MRI brain imaging experiment.

Objectives:

  • To provide the overall project direction with a project management structure that ensures an efficient operational management including administrative, financial and legal issues, and appropriate liaison with the European Commission (EC).

  • To maintain and maximise polarisation of mXe with Spin-exchange Optical Pumping, explore Dynamic Nuclear Polarization (DNP).

  • To explore best K-space sampling strategies and simulate setup’s response to γ radiation.

  • To define and develop the hardware and software configuration of the γMRI prototype.

  • To develop a biophysical model of mXe tracer distribution and dynamics to perform first preclinical proof-of-principle γMRI brain imaging experiment and apply the technique to a rodent model of stroke.

  • To design a plan for optimal communication and undertake extensive dissemination activities to maximize awareness of this innovation.

Current Status:

At this moment, the project has been recently launched and all the corresponding Work Packages are starting according to the plan.

Project Work Plan: