Technology:
Gamma MRI will develop a clinical molecular imaging device based on the physical principle of anisotropic gamma emission from hyperpolarised metastable xenon, based on a revolutionary technology, allowing the simultaneous exploitation of the sensitivity of gamma (γ) detection and the spatial resolution and flexibility of MRI.
Expected Results:
At the end of the project, Gamma MRI will deliver a working prototype for in vivo molecular imaging, including the production of hyperpolarised gamma-emitting xenon isomers, preserving hyperpolarisation until delivery to targeted organ, developing advanced image acquisition and reconstruction using physics- and artificial intelligence- based approaches, designing and assembling the prototype upon a low field versatile magnet and implementing the first preclinical Gamma MRI brain imaging experiment.
Objectives:
To provide the overall project direction with a project management structure that ensures an efficient operational management including administrative, financial and legal issues, and appropriate liaison with the European Commission (EC).
To maintain and maximise polarisation of mXe with Spin-exchange Optical Pumping, explore Dynamic Nuclear Polarization (DNP).
To explore best K-space sampling strategies and simulate setup’s response to γ radiation.
To define and develop the hardware and software configuration of the γMRI prototype.
To develop a biophysical model of mXe tracer distribution and dynamics to perform first preclinical proof-of-principle γMRI brain imaging experiment and apply the technique to a rodent model of stroke.
To design a plan for optimal communication and undertake extensive dissemination activities to maximize awareness of this innovation.